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HORIZON-HLTH-2024-TOOL-05-06-two-stage: Innovative non-animal human-based tools and strategies for biomedical research

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This topic supports activities aimed at achieving expected impacts of Destination 5, "Unlocking the full potential of new tools, technologies, and digital solutions for a healthy society." Proposals should aim to deliver results that contribute to the following outcomes: utilizing more human-relevant tools and strategies in research, reducing animal use in biomedical research, providing access to improved human-relevant tools for health technology developers, and benefiting healthcare providers and patients with innovative tools for improved disease prediction, prevention, and treatment.

Innovative non-animal human-based tools and strategies for biomedical research

  • HORIZON-HLTH-2024-TOOL-05-06-two-stage
  • Planned opening date: 30 March 2023; Deadline dates: 19 September 2023 17:00:00 Brussels time; 11 April 2024 17:00:00 Brussels time
  • 4.000.000 to 8.000.000 €; 4 grants


The proposal(s) should develop and/or use tools and strategies that address critical areas of biomedical research where animal-models are currently used but are of limited translational value for investigation and development of prevention and treatment. Such advanced tools and strategies should aim at a better understanding of the pathogenesis of disorders that feature a high impact on public health and exhibit a high rate of animal use or severe animal suffering, and enable to develop biomedical concepts with increased translational value, thereby ultimately leading to improved disease prediction, prevention and treatment.

Proposals under this topic should aim for delivering results that are directed towards and contributing to several of the following Expected Outcomes:

  • Researchers utilise tools and strategies that are more relevant to the human situation as compared to the currently used animal models.
  • Fewer live animals are used in biomedical research.
  • Health technology developers will get access to improved human-relevant tools or strategies allowing for a faster pace of innovation.
  • Legislators and regulators will benefit from strengthened EU leadership in non-animal based biomedical research that is socially accepted and sustainable.
  • Healthcare providers and patients will benefit from innovative tools or strategies opening up novel biomedical concepts enabling improved disease prediction, prevention and treatment.

The proposals should address all of the following aspects:

  • The innovative tools and strategies should include a variety of technologies and methodological approaches such as –omics and other high-throughput procedures, human-derived cell-based material, organoids, micro-physiological systems, and in-silico models.
  • The newly proposed tools and strategies should demonstrably advance the state-of-the-art in specific areas of biomedical research.
  • Prospects and avenues for dissemination, knowledge sharing, uptake or translation into health policies of the proposed tools and strategies within the EU should be provided.
  • Aspects such as harm and cost-benefit assessment as well as ease of production with respect to current practices should also be considered.
  • Criteria for model qualification and standardisation should be developed in well-justified use-case contexts to demonstrate their translational values.

Proposals could consider the involvement of the European Commission's Joint Research Centre (JRC) to provide added-value regarding such aspects as supporting validation of emerging approaches, promotion of research results, and the interfacing with the regulatory community. In this respect, the JRC is open to collaborate with any successful proposal after the selection process has been completed.

This topic requires the effective contribution of social sciences and humanities (SSH) disciplines and the involvement of SSH experts, institutions as well as the inclusion of relevant SSH expertise, in order to produce meaningful and significant effects enhancing the societal impact of the related research activities.

Notes fom the KoWi-Webinar:

  • collaborative research – at least 3 different independent legal entities established in at least 3 different EU member states or associated countries – at least one established in a member state.
  • Project duration from 2-5 years
  • Alignment with EU policy priorities & SDGs
  • 2-stage procedure: 10 pages preproposal; full proposal 45 pages (should be in the head already at 1. Stage); standard application form – 3 parts
  • Time-to-grant: normally 5 + 3 months; evaluation 5 months; grant agreement 3 months à for this call June 2024 Start of the grant

For more information see here.


For more information and support please contact the EU-Büro

Eveline Fräßdorf

Beratung EU-Förderungen

t: 450-576024

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