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New Charité 3R Toolbox

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The Charité 3R Toolbox is designed to help scientists – in particular young scientists within academia – to find alternatives to animal research, use fewer laboratory animals, improve the welfare of these animals and, in doing so, enhance the quality of the scientific research.

About 60 years ago, W.M.S. Russell and R.L. Burch developed the ‘principles of the 3Rs’which they published in their book "The Principles of Humane Experimental Technique". Since then, many scholars have proposed the inclusion of additional Rs to supplement the existing three. The Charité 3R Toolbox is structured along the lines of the 6R model proposed by the BIH QUEST Center (position paper Strech & Dirnagl, 2019) which adds robustness, registration and reporting to the existing 3Rs of replacement, reduction and refinement. The Charité 3R Toolbox simplifies the retrieval of relevant, high-quality information and facilitates the implementation of the 6Rs.


Charité 3R Toolbox


We welcome all feedback. Should you have any comments or suggestions, please email at c3r-education(at)

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