Event for expert public only
PrecisionTox "Café Scientifique" with Prof. Beate Escher - "Cell-based bioassays for Precisiontox ….. and what else can you do with them?"
Cell-based bioassays are at the bottom of the food chain in PrecisionTox but they will hopefully provide relevant information on chemicals’ effects on the cellular level. This webinar will give an introduction to cell-based in vitro assays and how they are used for mechanistic research on cellular toxicity pathways, for the risk assessment of chemicals and in environmental monitoring & biomonitoring. A particular focus will be put on the exposure in cell-based bioassays, introducing tools on how to measure and model the exposure in high-throughput screening assays, which are performed on multi-well plates in small volumes of 20 to 100 µL. A pragmatic experimental workflow to assess stability of test compounds in bioassay media will be presented. A combination of measurements and modeling sheds further light on the exposure, which will help to interpret the results and set the detected effects in context of baseline toxicity.
Organizational and administrative matters
Prof. Beat Escher
Head of Department of Cell Toxicology at the Helmholtz Centre for Environmental Research in Leipzig
and Professor at the Eberhard Karls University Tübingen
4:00 PM – 5:30 PM CET
Online event via Zoom