Participating labs and imaging modalities

At Charité and MDC, various research groups have built up state-of-the-art research laboratories and internationally recognized expertise in the field of preclinical imaging, which they make available as core facilities to other research groups. EPIC aims to network these core facilities as well as other imaging modality devices to facilitate their use by other researchers, and to enable consistent implementation of 3R approaches.

CT, MRI, PET, SPECT, Optical Imaging, Ultrasonography, Microscopy …

The number and range of imaging methods in preclinical research is nowadays comparable to the clinical field. Each method has its specific strengths and areas of application. For research groups with a non-imaging focus it is often difficult to recognize the possibilities of imaging technologies for their own research, to find and select the appropriate methods, and to design the appropriate experiments. EPIC aims to provide a platform for all preclinical imaging modalities at the Charité and MDC, with an emphasis on developing standardized protocols for multimodal imaging. The following register lists all imaging laboratories currently participating in EPIC.

Charité Berlin Experimental Radionuclide Imaging Center (BERIC)

Description

The BERIC is located at the Department of Nuclear Medicine at the Charité Campus Virchow-Klinikum and offers equipment for radionuclide imaging in small animals for oncological, neurological, cardiological and inflammatory diseases.

<sup>99m</sup>Tc-Pertechnetat SPECT/CT, Maus | © Nicola Beindorff, Berlin Experimental Radionuclide Imaging Center, Charité - Universitätsmedizin Berlin — ^99mTc-Pertechnetat SPECT/CT, Maus | © Nicola Beindorff, Berlin Experimental Radionuclide Imaging Center, Charité - Universitätsmedizin Berlin

Devices

PET/CT (nanoScan, Mediso)

SPECT/CT (nanoSPECT/CT plus, Bioscan/Mediso)

3T MRT – see PMC

Website

Preclinical research - Berlin Experimental Radionuclide Imaging Center (BERIC) (in German)

Publications

Research database of the Charité

Contact

Dr. Nicola Beindorff

nicola.beindorff(at)charite.de

Charité 7T Experimental MRIs

Description

The Charité 7T experimental MRIs at Charité Campus Mitte offer two 7T small animal MRIs for preclinical research with a focus on neuroimaging.

High resolution ceAngio, Maus | © Philipp Boehm-Sturm und Susanne Mueller, 7T Experimental MRIs, Charité - Universitätsmedizin Berlin

Devices

7T Bruker BioSpec

7T Bruker Pharmascan

Website

NeuroCure Cluster of Excellence

Publications

Research database of the Charité - Dr. Philipp Boehm-Sturm

Contact

Dr. Philipp Boehm-Sturm

philipp.boehm-sturm(at)charite.de

Dipl.-Ing. Susanne Mueller

susanne.mueller1(at)charite.de

Charité Preclinical MRI Center (PMC)

Description

The PMC at Charité Campus Virchow-Klinikum offers a 3T small animal MRI with focus on cardiac imaging and high throughput measurements. The lab is located directly next to the BERIC, this allows multimodal measurements in combination with nuclear medicine methods.

Cine MRT, Ratte HF 320/min | © Daniel Messrohli, Preclinical MRI Center, Charité - Universitätsmedizin Berlin

Devices

3T MRT (MR Solutions)

Website

Preclinical MRI Center (in German)

Publications

Research database of the Charité

Contact

PD Dr. Daniel Messroghli

daniel.messroghli(at)charite.de

Charité Tumor Targeting Group/Small Animal Optical Imaging Facility

Description

The small animal optical imaging facility at the Charité Campus Virchow-Klinikum provides instrumentation and know-how for fluorescent and bioluminescent imaging of small animals (mice, rats, etc.) in vivo as well as small-animal white-light endoscopy.

Optical Imaging | © Carsten Grötzinger, Small Animal Optical Imaging Facility, Charité - Universitätsmedizin Berlin

Devices

Pearl Near-infrared fluorescent imager (LiCor)

Maestro Small animal fluorescent imager (Cri)

Colonview Endoscopic system (STORZ)

FCM1000 Endoscopic near-infrared fluorescent confocal microscope (Leica)

Website

AG Tumortargeting (in German)

Publications

Research database of the Charité

Contact

Dr. Carsten Grötzinger

carsten.groetzinger(at)charite.de

Charité Institute of Cell Biology and Neurobiology/microCT Labor

Description

The microCT lab at Charité Campus Mitte provides hardware and expertise for small animal high resoliution CT.

Aufnahme eines Micro-CT einer Maus; Copyright Charité; Foto: Theres Schaub, Institut für Zell- und Neurobiologie, Charité — Micro-CT, Maus | © Charité / Foto: Theres Schaub, Institut für Zell- und Neurobiologie/microCT Labor, Charité - Universitätsmedizin Berlin

Devices

microCT (explore Locus, GE)

MicroCT, Maus | © Theres Schaub, Institut für Zell- und Neurobiologie/microCT Labor, Charité - Universitätsmedizin Berlin

Website

Institute of Cell Biology and Neurobiology

Publications

Research database of the Charité

Contact

Dr. Theres Schaub

theres.schaub(at)charite.de

Charité Institute of Physiology/Small Animal Ultrasonography

Description

The Institute of Physiology at the Charité Campus Mitte is equipped with a state-of-the-art small animal ultrasonography system and can provide expertise in the field of echocardiography.

Ultraschall, Herz Maus | © Niklas Hegemann, Institut für Physiologie, Charité – Universitätsmedizin Berlin

Devices

Vevo 3100 Workstation

MX-250 & MX-400 Transducers

Website

Institute of Physiology

Publications

Research database of the Charité - Univ.-Prof. Dr. Wolfgang Kübler

Research database of the Charité - Niklas Hegemann

Contact

Univ.-Prof. Dr. Wolfgang Kübler

wolfgang.kuebler(at)charite.de

Niklas Hegemann

niklas.hegemann(at)charite.de

MDC Preclinical Research Center

Description

The Preclinical Research Center at the Max-Delbrück-Centrum for Molecular Medicine at Campus Berlin-Buch offers a wide spectrum of modalities and expertise for multimodal imaging investigations (MRI, CT, ultrasound, Photoacoustic Imaging, multiphoton microscopy) for animal research.